Clostridium difficile shows no trade-off between toxin and spore production within the human host
نویسندگان
چکیده
منابع مشابه
Spore Formation and Toxin Production in Clostridium difficile Biofilms
The ability to grow as a biofilm can facilitate survival of bacteria in the environment and promote infection. To better characterize biofilm formation in the pathogen Clostridium difficile, we established a colony biofilm culture method for this organism on a polycarbonate filter, and analyzed the matrix and the cells in biofilms from a variety of clinical isolates over several days of biofilm...
متن کاملFidaxomicin Inhibits Spore Production in Clostridium difficile
Fidaxomicin (FDX) is a novel antimicrobial agent with narrow-spectrum and potent bactericidal activity against Clostridium difficile. In recent clinical trials, FDX was superior to vancomycin in preventing recurrences of C. difficile infection. A possible mechanism of reducing recurrence may be through an inhibitory effect on sporulation. The effect of FDX and its major metabolite, OP-1118, on ...
متن کاملEFFECT OF AMYGDALUS COMMUNIS ON GROWTH AND TOXIN PRODUCTION OF CLOSTRIDIUM DIFFICILE
It is known that the major etiologic agent of pseudomembranous colitis in man is Clostridium difficile. With respect to traditional use of almond paste in the treatment of infantile diarrhea, we studied the effects of the aqueous extract of Amygdalus communis (AEAC) on the growth and toxin production of Clostridium difficile in culture medium and the rabbit ligated ileal loop. Three groups...
متن کاملFidaxomicin inhibits toxin production in Clostridium difficile.
OBJECTIVES Fidaxomicin, which was recently approved for the treatment of Clostridium difficile-associated diarrhoea, demonstrates narrow-spectrum bactericidal activity via inhibition of RNA polymerase. In this study we evaluated its inhibitory activity versus C. difficile toxin gene expression and toxin production by quantifying toxin mRNA and protein. METHODS The effects of fidaxomicin, its ...
متن کاملClostridium difficile Spore-Macrophage Interactions: Spore Survival
BACKGROUND Clostridium difficile is the main cause of nosocomial infections including antibiotic associated diarrhea, pseudomembranous colitis and toxic megacolon. During the course of Clostridium difficile infections (CDI), C. difficile undergoes sporulation and releases spores to the colonic environment. The elevated relapse rates of CDI suggest that C. difficile spores has a mechanism(s) to ...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 2018
ISSN: 0022-2615,1473-5644
DOI: 10.1099/jmm.0.000719